研究業績

　論文

▶ Real-time imaging of human endothelial-to-hematopoietic transition in vitro using pluripotent stem cell derived hemogenic endothelium.
Yoneda Y, Kato H, Maezawa Y, Yokote K, Nakanishi M.
Biophys Physicobiol. 2024 Mar 22;21(Supplemental):e211015. doi: 10.2142/biophysico.bppb-v21.s015. eCollection 2024.

▶ Heart failure promotes multimorbidity through innate immune memory.
Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E,
Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I.
Sci Immunol. 2024 May 24;9(95):eade3814. doi: 10.1126/sciimmunol.ade3814. Epub 2024 May 24.

▶ Chemical genomics reveals targetable programs of human cancers rooted in pluripotency.
Orlando L, Benoit YD, Reid JC, Nakanishi M, Boyd AL, García-Rodriguez JL, Tanasijevic B, Doyle MS, Luchman A, Restall IJ, Bergin CJ, Masibag AN, Aslostovar L,
Di Lu J, Laronde S, Collins TJ, Weiss S, Bhatia M.
Cell Chem Biol. 2023 Jul 20;30(7):780-794.e8. doi: 10.1016/j.chembiol.2023.06.004. Epub 2023 Jun 27.

▶ Developing CRISPR/Cas9-Mediated Fluorescent Reporter Human Pluripotent Stem-Cell Lines for High-Content Screening.
Vojnits K, Nakanishi M, Porras D, Kim Y, Feng Z, Golubeva D, Bhatia M.
Molecules. 2022 Apr 9;27(8):2434. doi: 10.3390/molecules27082434.

▶ Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions.
Orlando L, Tanasijevic B, Nakanishi M, Reid JC, García-Rodríguez JL, Chauhan KD, Porras DP, Aslostovar L, Lu JD, Shapovalova Z, Mitchell RR, Boyd AL, Bhatia M.
Cell Rep. 2021 Mar 9;34(10):108818. doi: 10.1016/j.celrep.2021.108818.

▶ Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients.
Aslostovar L, Boyd AL, Benoit YD, Di Lu J, Garcia Rodriguez JL, Nakanishi M, Porras DP, Reid JC, Mitchell RR, Leber B, Xenocostas A, Foley R, Bhatia M.
Cell Rep Med. 2021 Feb 16;2(2):100202. doi: 10.1016/j.xcrm.2021.100202. eCollection 2021 Feb 16.

▶ Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells.
Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M.
Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013. Epub 2019 Apr 11.

▶ Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche.
Boyd AL, Reid JC, Salci KR, Aslostovar L, Benoit YD, Shapovalova Z, Nakanishi M, Porras DP, Almakadi M, Campbell CJV, Jackson MF, Ross CA, Foley R, Leber B,
Allan DS, Sabloff M, Xenocostas A, Collins TJ, Bhatia M.
Nat Cell Biol. 2017 Nov;19(11):1336-1347. doi: 10.1038/ncb3625. Epub 2017 Oct 16.

▶ Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.
Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D,
Meissner A, Weir G, Zhou Q.
Nat Biotechnol. 2015 Aug;33(8):882. doi: 10.1038/nbt0815-882a.

▶ Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.
Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D,
Meissner A, Weir G, Zhou Q.
Nat Biotechnol. 2014 Dec;32(12):1223-30. doi: 10.1038/nbt.3082. Epub 2014 Nov 17.

▶ In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes.
Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q.
Elife. 2014 Jan 1;3:e01846. doi: 10.7554/eLife.01846.

▶ Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN.
Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T,
Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J.
Stem Cells Transl Med. 2013 Apr;2(4):265-73. doi: 10.5966/sctm.2012-0154. Epub 2013 Mar 22.

▶ Glycome diagnosis of human induced pluripotent stem cells using lectin microarray.
Tateno H, Toyota M, Saito S, Onuma Y, Ito Y, Hiemori K, Fukumura M, Matsushima A, Nakanishi M, Ohnuma K, Akutsu H, Umezawa A, Horimoto K,
Hirabayashi J, Asashima M.
J Biol Chem. 2011 Jun 10;286(23):20345-53. doi: 10.1074/jbc.M111.231274. Epub 2011 Apr 6.

▶ Inhibitory Smad proteins promote the differentiation of mouse embryonic stem cells into ependymal-like ciliated cells.
Nishimura Y, Kurisaki A, Nakanishi M, Ohnuma K, Ninomiya N, Komazaki S, Ishiura S, Asashima M.
Biochem Biophys Res Commun. 2010 Oct 8;401(1):1-6. doi: 10.1016/j.bbrc.2010.08.099. Epub 2010 Aug 31.

▶ Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture.
Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Furue MK.
Int J Dev Biol. 2010;54(8-9):1287-94. doi: 10.1387/ijdb.103173ya.

▶ Text mining meets workflow: linking U-Compare with Taverna.
Kano Y, Dobson P, Nakanishi M, Tsujii J, Ananiadou S.
Bioinformatics. 2010 Oct 1;26(19):2486-7. doi: 10.1093/bioinformatics/btq464. Epub 2010 Aug 12.

▶ TIF1beta regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.
Seki Y, Kurisaki A, Watanabe-Susaki K, Nakajima Y, Nakanishi M, Arai Y, Shiota K, Sugino H, Asashima M.
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10926-31. doi: 10.1073/pnas.0907601107. Epub 2010 May 27.

▶ In vitro organogenesis from undifferentiated cells in Xenopus.
Asashima M, Ito Y, Chan T, Michiue T, Nakanishi M, Suzuki K, Hitachi K, Okabayashi K, Kondow A, Ariizumi T.
Dev Dyn. 2009 Jun;238(6):1309-20. doi: 10.1002/dvdy.21979.

▶ Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.
Nakanishi M, Kurisaki A, Hayashi Y, Warashina M, Ishiura S, Kusuda-Furue M, Asashima M.
FASEB J. 2009 Jan;23(1):114-22. doi: 10.1096/fj.08-111203. Epub 2008 Sep 22.

▶ Pancreatic tissue formation from murine embryonic stem cells in vitro.
Nakanishi M, Hamazaki TS, Komazaki S, Okochi H, Asashima M.
Differentiation. 2007 Jan;75(1):1-11. doi: 10.1111/j.1432-0436.2006.00109.x.